Preparation Of Ursolic Acid-loaded Eudragit-e Nanocarrier

AUTHOR

Rajat Lathwal*

ABSTRACT

Ursolic acid (UA), a triterpenoid could hinder the progression of tumor cells but its potential for clinical utilization is significantly hindered by its poor solubility due to its hydrophobic nature. The present study is aimed to develop Ursolic acid-loaded Eudragit-E nanoparticles (UENPs) using the nanoprecipitation technique. We observed that UENPs possess particle size in the 22 – 39 nm range and an encapsulation efficiency of 60%. Furthermore, Eudragit-E at 8 mg/ml and poloxamer at 0.8% w/w were competent to produce isolated and free-flowing nanoparticles. These findings suggest the utilization of UA-entrapped Eudragit-E nanoparticles as an advanced drug delivery tool to combat cancer.

 Keywords: Anti-cancer activity, Nanoplatforms, Polymeric Particle size, Ursolic acid