In vitro evaluation of antimicrobial property of nanoparticles and chlorhexidine against Streptococcus pneumoniae

AUTHOR

Amit Kumar

ABSTRACT 

This study used ionic liquids to successfully create a positively charged copper nanocomplex that served as a nanocarrier for chlorhexidine. Interestingly, this nanocomplex may deliver the antibacterial drug with a synergistic outcome. In this study, positively charged zinc nanoparticles (CZNPs) loaded with chlorhexidine were examined using UV-visible spectroscopy, TEM, X-ray diffraction, FTIR, and PSA. The effectiveness of loading, the drug release profile, and the antibacterial properties of chlorhexidine were then assessed. For CZNPs, an average size of 42.65 nm was found. As a result of their consistent release of chlorhexidine, the CZNPs are a more potent antibacterial agent while treating Streptococcus pneumoniae.  

 Keywords: Antibacterial, Bacteriostatic, Chlorhexidine, Nanoparticle