Excess intake of Glucocorticoids leading to Osteoporosis

AUTHOR

Hitesh Kaushik^1*, Mahak Saxena¹

ABSTRACT  

Glucocorticoids are potent medications that reduce inflammation and boost your immune system to treat a variety of illnesses. Basal GC levels are crucial for intermediate metabolism and play a role in the growth and homeostasis of a variety of bodily tissues, including the skeleton, from a physiological standpoint. Numerous investigations on mammals have shown that GC hormones play a beneficial effect in bone remodelling and modelling by promoting osteoblastogenesis, which preserves the bone architecture. Although the so-called stress hormones’ pharmaceutical effects have received considerable attention, little is known about the impact of endogenous GCs on bone mineral metabolism as a result of the endocrine stress response in vertebrates. Additionally, stress reactions differ among vertebrate lineages and depend on the stressor (such as mineral requirements, physical stress, and psychological stress), life cycle events (such as migration and ageing), and stressor (such as starvation, predation, and environmental change). This review aims to provide an overview of how endogenous GCs affect bone metabolism. Osteoporosis is a medical disorder that causes bones to become brittle and more prone to breaking. Stress, which causes physical, emotional, and intellectual reactions, is a typical bodily response to change.

 Keywords: Glucocorticoids, Stress, Osteoblastogenesis, Osteoporosis